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Weight loss and lean mass loss from burn induced catabolism can be more rapidly restored when the anabolic steroid oxandrolone is added to optimum nutrition compared to nutrition alone. It was postulated that oxandrolone was a "rejuvenating" agent because it restored the lean mass lost during weight loss due to decreased caloric intake. This observation has been supported in several studies comparing oxandrolone therapy with nutrition alone. When the metabolic rate is reduced during lean tissue preservation with nutritional and anabolic/reducing therapy, it generally results in loss of lean body weight and muscle mass [12, 13] although this mechanism may be more prominent during weight loss and/or muscle gain in athletes [10, 11, 16, 17]. Oxandrolone does not increase energy expenditure during caloric restriction compared to an energy-restricted (e.g. diet alone or diet plus anabolic/reducing agents) state . There are several advantages to weight loss with oxandrolone. First off, as with other anabolic steroids, oxandrolone can be used during short periods of time in order to provide a faster response period. The drug also has a long half-life, which would theoretically allow the effects to last longer in a person who has previously experienced such effects. Second, oxandrolone does not produce a large amount of side effects and there is no evidence of abuse or overdose with this agent . In addition, many studies have shown that oxandrolone supplementation is not very dangerous. The adverse effects in the body to which oxandrolone supplementation may be particularly dangerous include the following: (1) depression, suicidal tendencies, anxiety, and depression; (2) urinary alkalosis; (3) hypertension; (4) liver injury, hypokalemia, and alkaloid toxicity; (5) hepatotoxicity [18, 20] (6) increased serum levels of hepatic alkaloids; and (7) increased serum levels of catecholamines such as catecholamines, epinephrine, norepinephrine, and norephinephrine. It has been found that oxandrolone supplementation at low to moderate doses can enhance the efficacy of pharmacological treatment of obesity [21, 21]. One study comparing 4 doses (40 mg each) of oxandrolone, a diet without a significant difference in weight loss, showed a 2.9-% increase in aldosterone in obese subjects during oxandrolone treatment . One study comparing 2 doses (0.2–2 mg) of oxandrolone did not show a significant difference in weight change. Related Article: